This collection includes correspondence, manuscripts (lectures and articles), research grant material, research data, and participation in organizations, such as, the American Society of Naturalists (President, 1968), Genetics Society of America (President, 1963), and the National Research Council. Of particular note, are the detailed data related to Drosophila eye pigment, and human chromosomes.

William Jacob Robbins (1890-1978, APS 1941) was a botanist and physiologist. From 1937 to 1957 he was director of the New York Botanical Garden. His research focused on culture methods of plants in relation to biochemistry and nutrition, especially on the synthetic abilities of fungi. His studies paralleled the scientific agenda of the Rockefeller Foundation, an agency with which he was closely associated for years as adviser and trustee. He was perhaps the most influential botanist in the National Academy of Sciences (NAS) during the early postwar era, and a principal participant in the plans for the global reconstruction of science. Robbins served as president of the American Philosophical Society from 1956 to 1959.

The maize geneticist Barbara McClintock (1902-1992) is credited with the discovery of "jumping genes," that is chromosomal "crossing over" and translocation. She received the Nobel Prize in Physiology or Medicine in 1983. The collection is organized into six series: I. Correspondence, 1931-1991; II. Subject files, 1938-1989; III. Works by McClintock, 1944-1989; IV. Works by others, 1927-1991; V. Research notes, notebooks, and card files, 1930s-1990s ; VI. Photographs, 1928-1991.